Positive regulation of defense response to virus by host

Across TCGA cell cohorts, RNA activity of the Positive regulation of defense response to virus by host pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX60, EHD4, and TNFSF10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of defense response to virus by host activity versus DDX60 in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DDX60 →	+1.359	+0.233	<.001	<.001	3	6
BLOOD_Lymphoma	EHD4 →	+1.156	+0.232	.001	.003	3	4
LUNG_NSCLC_LUSC	TNFSF10 →	+2.943	+0.296	<.001	<.001	3	4
BLOOD_Lymphoma	SNPH →	+0.633	+0.183	.005	.005	3	4
BLOOD_Lymphoma	RAB38 →	+1.182	+0.223	.001	<.001	3	4
BLOOD_Lymphoma	HELB →	+0.954	+0.256	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002230 vs DDX60 — BLOOD_Lymphoma

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