Innate immune response activating cell surface receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Innate immune response activating cell surface receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LST1, HLA-F, and THEMIS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Innate immune response activating cell surface receptor signaling pathway activity versus LST1 in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LST1 →	+0.780	+0.356	<.001	.006	3	6
GBM	HLA-F →	+0.715	+0.184	.001	<.001	3	6
LSCC	THEMIS2 →	+0.909	+0.506	<.001	.001	3	6
LSCC	LCP1 →	+1.006	+0.521	<.001	<.001	3	6
BRCA	KCNE1 →	+0.248	+0.143	.001	<.001	3	6
BRCA	SRGN →	+0.959	+0.206	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002220 vs LST1 — LSCC

Explore this scatter interactively →