Innate immune response activating cell surface receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Innate immune response activating cell surface receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROS1, CHST3, and PMP22, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Innate immune response activating cell surface receptor signaling pathway activity versus PROS1 in STOMACH (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PROS1 →	-3.364	-1.451	.002	.001	3	7
BREAST	CHST3 →	-2.020	-1.014	<.001	<.001	3	7
BREAST	PMP22 →	-2.424	-0.997	.003	.001	3	7
BREAST	CSF1 →	-2.363	-1.078	<.001	<.001	3	7
BLOOD_Lymphoma	ITGAV →	-1.511	-0.921	<.001	<.001	3	7
BREAST	DPY19L1 →	-1.296	-0.739	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002220 vs PROS1 — STOMACH

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