Somatic diversification of immune receptors

Across TCGA patient cohorts, RNA activity of the Somatic diversification of immune receptors pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DBR1, MSH2, and STIM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immune receptors activity versus DBR1 in LSCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DBR1 →	+0.312	+0.034	<.001	.001	3	7
HNSC	MSH2 →	+0.493	+0.080	<.001	<.001	3	7
LUAD	STIM1 →	-0.350	-0.035	<.001	.001	3	7
LUAD	TOP2A_S1247 →	+1.149	+0.033	<.001	<.001	3	6
LSCC	TOP2A_S1377 →	+0.963	+0.042	.001	<.001	3	6
LUAD	TPX2 →	+0.726	+0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002200 vs DBR1 — LSCC

Explore this scatter interactively →