Somatic diversification of immune receptors

Across TCGA cell cohorts, RNA activity of the Somatic diversification of immune receptors pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIRIP3, RBL1, and HMGB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immune receptors activity versus HIRIP3 in BLOOD_Lymphoma (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HIRIP3 →	+0.501	+0.126	.005	.007	2	9
BLOOD_Leukemia	RBL1 →	+0.558	+0.181	<.001	.001	3	8
LIVER	HMGB2 →	+1.436	+0.367	.002	.005	3	8
BLOOD_Myeloma	MCM7 →	+1.742	+0.251	.002	.003	2	9
BLOOD_Myeloma	TARDBP →	+0.569	+0.263	.001	.003	3	8
BLOOD_Leukemia	NUSAP1 →	+0.775	+0.178	.003	.002	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002200 vs HIRIP3 — BLOOD_Lymphoma

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