Cap-dependent translational initiation

Across TCGA cell cohorts, RNA activity of the Cap-dependent translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD4B, CPEB4, and DLG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD4B grouped by Cap-dependent translational initiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MFSD4B →	+0.558	+0.183	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CPEB4 →	+1.301	+0.157	.001	<.001	3	4
LUNG_NSCLC_LUSC	DLG1 →	-1.100	-0.196	.008	<.001	3	4
BLOOD_Lymphoma	SIGIRR →	+2.089	+0.121	.007	.005	3	4
LUNG_SCLC	USP47 →	+0.788	+0.159	.001	.001	3	4
CNS	SHPRH →	+0.499	+0.163	.007	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD4B by Cap-dependent translational initiation activity — KIDNEY

Explore this box plot interactively →