Cytoplasmic translation

Across TCGA cell cohorts, RNA activity of the Cytoplasmic translation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPS5, RNF24, and NAA50, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COPS5 grouped by Cytoplasmic translation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	COPS5 →	-1.036	-0.633	<.001	.003	3	5
CNS	RNF24 →	+1.061	+0.262	.002	.009	2	5
KIDNEY	NAA50 →	-0.905	-0.454	.006	.002	3	4
LIVER	RECQL4 →	-1.030	-0.289	.003	.005	3	4
BLOOD_Lymphoma	KDM4B →	+1.002	+0.474	<.001	<.001	3	4
LUNG_NSCLC_LUAD	FIP1L1 →	-0.543	-0.214	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COPS5 by Cytoplasmic translation activity — BLOOD_Lymphoma

Explore this box plot interactively →