Store-operated calcium entry

Across TCGA patient cohorts, RNA activity of the Store-operated calcium entry pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITPR3_S2670, LCLAT1, and POMK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Store-operated calcium entry activity versus ITPR3_S2670 in COAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ITPR3_S2670 →	-0.417	-0.024	.001	.003	3	4
UCEC	LCLAT1 →	-0.313	-0.049	.002	.005	3	4
LSCC	POMK →	-0.397	-0.061	<.001	<.001	3	4
LSCC	BHLHE41_S122 →	+0.649	+0.069	<.001	<.001	3	4
BRCA	MDN1_T4898 →	-0.459	-0.032	.005	.002	3	4
HNSC	BDP1_S2451 →	-0.331	-0.068	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002115 vs ITPR3_S2670 — COAD

Explore this scatter interactively →