Store-operated calcium entry

Across TCGA patient cohorts, RNA activity of the Store-operated calcium entry pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, PLEKHG4B, and NKD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Store-operated calcium entry activity versus STIM1 in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STIM1 →	+0.702	+1.062	<.001	<.001	3	4
PDAC	PLEKHG4B →	-0.272	-0.441	.006	.003	3	4
CCRCC	NKD1 →	-0.512	-0.728	.002	<.001	3	3
COAD	SGMS2 →	+0.519	+0.466	.005	.005	3	3
GBM	PODN →	-0.845	-0.366	<.001	<.001	3	3
CCRCC	RPS26P11 →	-0.316	-0.445	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002115 vs STIM1 — OV

Explore this scatter interactively →