Store-operated calcium entry

Across TCGA cell cohorts, RNA activity of the Store-operated calcium entry pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDX1, BTBD19, and ITGB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDX1 grouped by Store-operated calcium entry-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CDX1 →	-0.143	-0.107	.008	.001	3	5
URINARY_TRACT	BTBD19 →	-0.121	-0.147	.006	.001	2	5
LARGE_INTESTINE	ITGB5 →	+0.217	+0.054	.003	.006	3	4
PANCREAS	DNAJB6 →	+0.333	+0.147	.004	<.001	3	4
BREAST	IRX3 →	-0.146	-0.088	.009	.003	3	4
LUNG_NSCLC_LUAD	FCRL1 →	-0.180	-0.085	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDX1 by Store-operated calcium entry activity — CNS

Explore this box plot interactively →