Store-operated calcium entry

Across TCGA cell cohorts, RNA activity of the Store-operated calcium entry pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL4, TMEM177, and TNNI2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Store-operated calcium entry activity versus RPL4 in OESOPHAGUS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPL4 →	-1.019	-0.256	<.001	.001	3	4
STOMACH	TMEM177 →	-0.675	-0.356	<.001	<.001	3	4
PANCREAS	TNNI2 →	+3.380	+0.331	<.001	<.001	3	4
PANCREAS	SYT8 →	+3.882	+0.310	<.001	<.001	3	4
OESOPHAGUS	TMEM185A →	+0.647	+0.200	.007	<.001	3	4
STOMACH	BNIP3L →	+1.901	+0.425	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002115 vs RPL4 — OESOPHAGUS

Explore this scatter interactively →