tRNA wobble base modification

Across TCGA cell cohorts, RNA activity of the tRNA wobble base modification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPST, SUPV3L1, and RND1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA wobble base modification activity versus MPST in BLOOD_Leukemia (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MPST →	+1.930	+0.579	.009	.005	2	7
SOFT_TISSUE	SUPV3L1 →	+0.580	+0.301	.002	<.001	3	6
BONE	RND1 →	+0.822	+1.380	.005	<.001	3	5
PANCREAS	SYNM →	-1.072	-0.690	.001	.001	3	5
OVARY	DNAJC14 →	-0.536	-0.746	.005	.006	3	5
OVARY	SAR1B →	-0.841	-0.846	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002097 vs MPST — BLOOD_Leukemia

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