Negative regulation of receptor internalization

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor internalization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLIN2, ANKS1A_S663, and ARFGEF1_S1079, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor internalization activity versus PLIN2 in PDAC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLIN2 →	+0.534	+0.042	.004	<.001	3	4
HNSC	ANKS1A_S663 →	-0.259	-0.061	.001	<.001	3	4
OV	ARFGEF1_S1079 →	-0.670	-0.037	.001	.002	3	4
BRCA	FSCN1 →	+0.452	+0.032	.001	.002	3	4
UCEC	PMM2 →	-0.278	-0.062	<.001	<.001	3	4
GBM	TNKS1BP1 →	-0.210	-0.045	.004	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002091 vs PLIN2 — PDAC

Explore this scatter interactively →