Regulation of receptor internalization

Across TCGA patient cohorts, RNA activity of the Regulation of receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, SLC25A19, and CHST4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor internalization activity versus LMNB1 in LUAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LMNB1 →	-0.510	-0.100	.005	.006	3	3
BRCA	SLC25A19 →	-0.378	-0.123	.003	.007	3	3
OV	CHST4 →	+0.846	+0.144	.005	.005	3	3
LUAD	E2F2 →	-0.544	-0.110	.006	.009	2	4
COAD	SFXN2 →	-0.510	-0.440	<.001	.001	3	3
PDAC	RPL21P4 →	-0.329	-0.144	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002090 vs LMNB1 — LUAD

Explore this scatter interactively →