Lens morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Lens morphogenesis in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF40, RPLP2, and ACTN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens morphogenesis in camera-type eye activity versus ARHGEF40 in HNSC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGEF40 →	+0.209	+0.052	.006	.008	3	6
OV	RPLP2 →	-0.287	-0.055	.002	.005	3	6
PDAC	ACTN4 →	+0.251	+0.040	<.001	<.001	3	5
OV	LARP1 →	-0.234	-0.060	.002	<.001	2	6
CCRCC	MAMDC2 →	+0.588	+0.056	.005	.009	3	5
BRCA	ACSF2 →	+0.573	+0.036	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002089 vs ARHGEF40 — HNSC

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