Lens morphogenesis in camera-type eye

Across TCGA cell cohorts, RNA activity of the Lens morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACC2, TMEM70, and DENND1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TACC2 grouped by Lens morphogenesis in camera-type eye-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TACC2 →	+1.237	+0.956	.001	.001	3	3
BLOOD_Leukemia	TMEM70 →	+0.720	+1.223	<.001	<.001	3	3
BLOOD_Leukemia	DENND1C →	-1.541	-1.265	.004	<.001	3	3
LUNG_NSCLC_LUAD	TXNDC2 →	-0.132	-0.702	<.001	.003	3	3
LUNG_NSCLC_LUAD	CNTROB →	-0.605	-0.587	<.001	.001	3	3
LUNG_NSCLC_LUAD	PIK3CD →	-0.779	-0.598	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TACC2 by Lens morphogenesis in camera-type eye activity — BLOOD_Leukemia

Explore this box plot interactively →