Lens development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Lens development in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, NOLC1_S538, and SH3BP4_S246, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens development in camera-type eye activity versus FERMT2 in BRCA (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FERMT2 →	+0.552	+0.039	<.001	<.001	3	8
BRCA	NOLC1_S538 →	-0.664	-0.032	<.001	<.001	3	8
LUAD	SH3BP4_S246 →	+0.438	+0.031	<.001	<.001	3	7
BRCA	VCL →	+0.343	+0.029	<.001	<.001	3	7
UCEC	TGFB1I1 →	+0.667	+0.048	.007	.009	3	7
BRCA	EIF3G →	-0.229	-0.043	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002088 vs FERMT2 — BRCA

Explore this scatter interactively →