Lens development in camera-type eye

Across TCGA pan-cancer cohorts, RNA activity of the Lens development in camera-type eye pathway differs between tumor and matched normal tissue in 16 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and KIRC, show the opposite pattern, with lower activity in tumor tissue.

THCA, KIRC, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Female	II,III,IV	−0.043	<.001	9	view →
KIRC	Male	III,IV	−0.022	<.001	9	view →
HNSC	All	All	−0.018	<.001	7	view →
UCEC	All	II,III,IV	−0.061	<.001	6	view →
BRCA	All	III,IV	−0.053	<.001	6	view →
LUAD	Female	All	−0.031	<.001	6	view →
LUSC	Male	All	−0.033	<.001	5	view →
LIHC	All	II,III,IV	+0.020	.002	5	view →
BLCA	Male	All	−0.032	.024	4	view →
KIRP	Male	All	+0.018	.010	3	view →
PAAD	All	All	+0.067	.016	2	view →
ESCA	Female	All	−0.063	.003	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 16 lineages.

GO:0002088–THCA

Open the THCA breakdown →