Lens development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Lens development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTH1R, KIF15, and SMOC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens development in camera-type eye activity versus PTH1R in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTH1R →	+0.717	+0.448	<.001	.001	3	5
HNSC	KIF15 →	-0.600	-0.448	<.001	.003	2	6
BRCA	SMOC2 →	+1.145	+0.637	<.001	<.001	3	5
BRCA	AOC3 →	+1.699	+0.829	<.001	<.001	3	5
BRCA	PRKD1 →	+0.713	+0.587	<.001	<.001	3	5
BRCA	PLAC9 →	+1.145	+0.656	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002088 vs PTH1R — UCEC

Explore this scatter interactively →