Lens development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Lens development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H1-0, MYL9, and MIEF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H1-0 grouped by Lens development in camera-type eye-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	H1-0 →	+2.516	+0.927	.001	.001	3	5
BREAST	MYL9 →	-2.764	-0.468	.001	.009	3	5
SOFT_TISSUE	MIEF2 →	-0.910	-0.917	.001	.002	3	4
LUNG_NSCLC_LUAD	ITSN1 →	-0.818	-0.507	<.001	.005	3	4
BREAST	FAS →	-1.068	-0.358	.001	.003	3	4
PANCREAS	MND1 →	-0.963	-0.266	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H1-0 by Lens development in camera-type eye activity — CNS

Explore this box plot interactively →