Lens development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Lens development in camera-type eye pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD81, ZNF208, and DUSP11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD81 grouped by Lens development in camera-type eye-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD81 →	-0.172	-1.120	.001	.002	3	3
LUNG_NSCLC_LUAD	ZNF208 →	-0.117	-1.150	.001	<.001	3	3
CNS	DUSP11 →	-0.196	-0.612	.007	.009	3	3
SKIN	ANAPC2 →	+0.227	+1.260	.006	<.001	3	3
OVARY	KRT80 →	+0.168	+1.483	.004	.001	3	3
BLOOD_Leukemia	ZNF500 →	+0.154	+1.045	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD81 by Lens development in camera-type eye activity — BLOOD_Leukemia

Explore this box plot interactively →