Lens development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Lens development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP1, NISCH, and KAT2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens development in camera-type eye activity versus VAMP1 in BLOOD_Leukemia (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VAMP1 →	-0.831	-0.769	.001	.003	3	6
SKIN	NISCH →	-0.573	-0.937	.003	.002	3	4
LUNG_NSCLC_LUAD	KAT2B →	-0.681	-0.538	.001	.005	2	5
LUNG_NSCLC_LUAD	SNAPC3 →	-0.608	-0.631	<.001	.001	3	4
SOFT_TISSUE	MINK1 →	-0.813	-0.299	<.001	.001	3	4
OVARY	PTPRR →	+1.954	+0.937	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002088 vs VAMP1 — BLOOD_Leukemia

Explore this scatter interactively →