Regulation of respiratory gaseous exchange by nervous system process

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory gaseous exchange by nervous system process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLGN2, CNTROB, and ADORA1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory gaseous exchange by nervous system process activity versus NLGN2 in STOMACH (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NLGN2 →	+2.516	+1.177	<.001	<.001	3	18
STOMACH	CNTROB →	+1.194	+1.412	<.001	<.001	3	13
STOMACH	ADORA1 →	+2.182	+1.429	.001	<.001	3	13
LUNG_SCLC	MAPK7 →	+1.013	+1.300	<.001	<.001	3	13
LUNG_NSCLC_LUSC	DLG4 →	+2.501	+1.374	<.001	<.001	3	12
LUNG_NSCLC_LUSC	SPEG →	+2.198	+1.328	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002087 vs NLGN2 — STOMACH

Explore this scatter interactively →