Protein depalmitoylation

Across TCGA patient cohorts, RNA activity of the Protein depalmitoylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX52, SLC16A3, and ZNF622_S143, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein depalmitoylation activity versus DDX52 in OV (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDX52 →	-0.349	-0.059	<.001	.003	3	6
CCRCC	SLC16A3 →	-0.297	-0.039	.001	.001	3	5
CCRCC	ZNF622_S143 →	-0.738	-0.056	<.001	<.001	3	5
CCRCC	EIF4A1 →	-0.160	-0.055	<.001	<.001	3	5
CCRCC	EIF4G2_S17 →	-0.476	-0.054	<.001	<.001	3	5
PDAC	ERO1A →	-0.522	-0.040	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002084 vs DDX52 — OV

Explore this scatter interactively →