Protein depalmitoylation

Across TCGA patient cohorts, RNA activity of the Protein depalmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYPLAL1, RNA5SP241, and FRMD7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein depalmitoylation activity versus LYPLAL1 in UCEC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LYPLAL1 →	+0.997	+0.197	<.001	<.001	3	3
UCEC	RNA5SP241 →	+1.078	+0.164	.003	<.001	3	3
GBM	FRMD7 →	-0.079	-0.095	.002	.001	3	3
CCRCC	DHFR2 →	+0.331	+0.126	.006	.005	3	3
CCRCC	ENPP7P4 →	+0.395	+0.113	.009	<.001	3	3
CCRCC	VWA8-AS1 →	+0.136	+0.122	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002084 vs LYPLAL1 — UCEC

Explore this scatter interactively →