Protein depalmitoylation

Across TCGA cell cohorts, RNA activity of the Protein depalmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPSB3, NASP, and ESRP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPSB3 grouped by Protein depalmitoylation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPSB3 →	-0.748	-1.218	<.001	.002	3	5
BREAST	NASP →	+0.775	+0.877	.004	.002	3	5
LUNG_SCLC	ESRP2 →	-2.172	-0.842	.002	.008	2	5
LARGE_INTESTINE	DHX58 →	-1.601	-1.167	.003	.003	3	4
SKIN	MICALL1 →	-0.507	-0.578	.007	.006	3	3
BLOOD_Leukemia	USP18 →	-1.615	-1.714	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPSB3 by Protein depalmitoylation activity — LARGE_INTESTINE

Explore this box plot interactively →