Protein depalmitoylation

Across TCGA cell cohorts, RNA activity of the Protein depalmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD17B, ABHD17C, and ADAT3, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein depalmitoylation activity versus ABHD17B in BLOOD_Leukemia (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ABHD17B →	+1.120	+0.124	<.001	<.001	3	15
LARGE_INTESTINE	ABHD17C →	+1.360	+0.093	<.001	<.001	3	13
LARGE_INTESTINE	ADAT3 →	+1.019	+0.080	<.001	<.001	3	10
BREAST	DEDD2 →	+0.688	+0.068	.003	.003	3	9
LUNG_NSCLC_LUAD	DAB2IP →	+1.245	+0.100	.001	<.001	3	9
BLOOD_Leukemia	MBD3 →	+0.531	+0.080	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002084 vs ABHD17B — BLOOD_Leukemia

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