Protein depalmitoylation

Across TCGA cell cohorts, RNA activity of the Protein depalmitoylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F5, TPM2, and NRG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, F5 grouped by Protein depalmitoylation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	F5 →	+0.365	+0.564	.002	.002	3	4
BLOOD_Myeloma	TPM2 →	+0.183	+0.424	.002	.002	3	4
BLOOD_Lymphoma	NRG2 →	+0.661	+0.531	.001	.002	3	3
CNS	TMPRSS11B →	-0.443	-0.208	.002	.002	3	3
BLOOD_Leukemia	TNIK →	+0.191	+0.176	.004	.006	3	3
LUNG_NSCLC_LUSC	PTBP1 →	-0.344	-0.326	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

F5 by Protein depalmitoylation activity — BLOOD_Myeloma

Explore this box plot interactively →