Protein depalmitoylation

Across TCGA cell cohorts, RNA activity of the Protein depalmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, CHST3, and ZFAND1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein depalmitoylation activity versus FLNA in LUNG_SCLC (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FLNA →	-1.356	-0.241	.002	<.001	3	5
BREAST	CHST3 →	-2.590	-0.300	<.001	<.001	3	4
URINARY_TRACT	ZFAND1 →	+0.799	+0.419	.002	.002	2	5
BLOOD_Myeloma	SLC35A3 →	+1.253	+0.409	.002	.002	3	4
URINARY_TRACT	RRP36 →	-0.485	-0.338	.005	.004	3	4
BREAST	MFGE8 →	-3.414	-0.241	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002084 vs FLNA — LUNG_SCLC

Explore this scatter interactively →