Optic cup morphogenesis involved in camera-type eye development

Across TCGA patient cohorts, RNA activity of the Optic cup morphogenesis involved in camera-type eye development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1A3, YKT6, and THTPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Optic cup morphogenesis involved in camera-type eye development activity versus ALDH1A3 in BRCA (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ALDH1A3 →	+0.660	+0.082	<.001	<.001	3	6
UCEC	YKT6 →	+0.268	+0.103	<.001	.001	3	5
CCRCC	THTPA →	-0.374	-0.083	<.001	.003	3	4
OV	DYNLL2 →	-0.389	-0.081	.005	<.001	3	4
HNSC	SOWAHC →	+0.322	+0.115	.003	.001	3	4
COAD	GUCY1A1 →	+0.338	+0.047	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002072 vs ALDH1A3 — BRCA

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