Epithelial cell maturation

Across TCGA patient cohorts, RNA activity of the Epithelial cell maturation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DGKQ, LIMA1_S93, and SHTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell maturation activity versus DGKQ in LUAD (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DGKQ →	-0.275	-0.030	<.001	.006	3	5
BRCA	LIMA1_S93 →	+1.463	+0.086	.001	<.001	3	4
COAD	SHTN1 →	+0.244	+0.027	.002	.002	3	4
COAD	FAM234A_S21 →	+0.438	+0.027	.001	.007	3	4
COAD	KCNAB2 →	-0.260	-0.030	.004	.003	3	4
GBM	ACSS3 →	+0.470	+0.045	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002070 vs DGKQ — LUAD

Explore this scatter interactively →