Columnar/cuboidal epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Columnar/cuboidal epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PROC, A1BG, and SSC5D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Columnar/cuboidal epithelial cell differentiation activity versus PROC in BRCA (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PROC →	+0.452	+0.021	.003	.004	3	7
OV	A1BG →	+0.484	+0.030	.001	.005	3	6
BRCA	SSC5D →	+0.529	+0.021	<.001	<.001	3	6
OV	HPX →	+0.593	+0.038	.001	.002	3	6
OV	HSPG2 →	+0.470	+0.036	.002	<.001	3	6
OV	LAMA4 →	+0.466	+0.029	.002	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002065 vs PROC — BRCA

Explore this scatter interactively →