Columnar/cuboidal epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Columnar/cuboidal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, FDXR, and SKA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Columnar/cuboidal epithelial cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDKN1A →	+2.266	+0.251	.005	.004	2	5
OVARY	FDXR →	+1.808	+0.289	<.001	.001	3	3
LUNG_NSCLC_LUSC	SKA1 →	-1.273	-0.243	.003	.005	3	3
LUNG_NSCLC_LUSC	TMEM237 →	-0.978	-0.283	.008	.006	3	3
LUNG_NSCLC_LUSC	STRBP →	-0.950	-0.256	<.001	.001	3	3
LUNG_NSCLC_LUSC	RHEBL1 →	-1.606	-0.343	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Columnar/cuboidal epithelial cell differentiation activity — OVARY

Explore this box plot interactively →