Columnar/cuboidal epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Columnar/cuboidal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM19, MCM8, and PSMB8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Columnar/cuboidal epithelial cell differentiation activity versus TMEM19 in LUNG_NSCLC_LUSC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TMEM19 →	+1.777	+0.360	.005	<.001	3	5
URINARY_TRACT	MCM8 →	+1.165	+0.496	.001	.003	3	5
LUNG_SCLC	PSMB8 →	-2.489	-0.176	.001	.006	3	5
LUNG_NSCLC_LUSC	EEA1 →	+1.172	+0.467	.006	.001	3	4
LARGE_INTESTINE	TUBA1B →	+1.075	+0.440	<.001	.006	3	4
LUNG_NSCLC_LUSC	WRAP53 →	+1.042	+0.422	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002065 vs TMEM19 — LUNG_NSCLC_LUSC

Explore this scatter interactively →