Epithelial cell development

Across TCGA cell cohorts, RNA activity of the Epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOLR1, SCEL, and KATNB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell development activity versus FOLR1 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FOLR1 →	+4.086	+0.295	.003	.001	3	7
PANCREAS	SCEL →	+3.281	+0.343	.001	<.001	3	6
PANCREAS	KATNB1 →	-0.903	-0.293	.005	.001	3	6
SKIN	BCL7A →	-1.280	-0.231	<.001	.001	3	6
SKIN	CAV1 →	+1.201	+0.161	.008	.009	3	6
LARGE_INTESTINE	PPP1R13L →	+2.175	+0.414	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002064 vs FOLR1 — OVARY

Explore this scatter interactively →