Blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Blood vessel endothelial cell proliferation involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNGT1, BCKDK, and MARS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNGT1 grouped by Blood vessel endothelial cell proliferation involved in sprouting angiogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GNGT1 →	-0.651	-0.950	.006	.006	3	4
OESOPHAGUS	BCKDK →	+0.703	+1.430	.004	.002	3	4
OESOPHAGUS	MARS2 →	+0.916	+1.534	.002	<.001	3	4
KIDNEY	KIF18A →	-0.653	-1.182	.008	.007	3	3
LUNG_NSCLC_LUSC	SUN2 →	-1.138	-1.833	.001	.001	3	3
PANCREAS	ASF1B →	+1.196	+1.436	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNGT1 by Blood vessel endothelial cell proliferation involved in sprouting angiogenesis activity — PANCREAS

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