Regulation of sodium ion transport

Across TCGA patient cohorts, RNA activity of the Regulation of sodium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP10, BMP1, and NUP85, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transport activity versus FKBP10 in CCRCC (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FKBP10 →	-0.542	-0.061	<.001	<.001	3	7
PDAC	BMP1 →	-0.389	-0.027	<.001	<.001	3	7
GBM	NUP85 →	-0.208	-0.072	<.001	<.001	3	7
CCRCC	P3H1 →	-0.407	-0.062	.001	<.001	3	6
PDAC	GPD1L →	+0.309	+0.026	<.001	<.001	3	6
GBM	MTURN →	+0.620	+0.061	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002028 vs FKBP10 — CCRCC

Explore this scatter interactively →