Regulation of sodium ion transport

Across TCGA patient cohorts, RNA activity of the Regulation of sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, FAM72A, and FAM72D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transport activity versus ANK3 in LUAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ANK3 →	+0.948	+0.658	<.001	<.001	3	5
BRCA	FAM72A →	-0.458	-0.412	<.001	<.001	3	5
BRCA	FAM72D →	-0.729	-0.557	.001	.001	3	5
BRCA	CIP2A →	-0.823	-0.755	<.001	<.001	3	5
BRCA	CDC6 →	-0.595	-0.545	.002	<.001	3	5
LUAD	CEP128 →	-0.521	-0.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002028 vs ANK3 — LUAD

Explore this scatter interactively →