Regulation of sodium ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of sodium ion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCHF7, SEMA6B, and PDIK1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARCHF7 grouped by Regulation of sodium ion transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MARCHF7 →	-0.423	-1.302	.004	.005	3	4
CNS	SEMA6B →	-0.305	-0.826	.001	.004	3	4
KIDNEY	PDIK1L →	-0.261	-1.106	.009	.002	3	4
CNS	PHEX →	-0.222	-0.853	.008	.006	3	3
CNS	CCDC93 →	-0.186	-0.845	.006	.004	3	3
CNS	C20orf173 →	-0.175	-0.945	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARCHF7 by Regulation of sodium ion transport activity — SOFT_TISSUE

Explore this box plot interactively →