Regulation of sodium ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHB, ENAH, and PPL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium ion transport activity versus PHB in LIVER (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PHB →	-0.827	-0.279	.009	.005	3	6
OESOPHAGUS	ENAH →	-1.007	-0.281	.005	.002	3	5
LARGE_INTESTINE	PPL →	+2.012	+0.231	.005	.005	3	5
STOMACH	ASRGL1 →	-3.288	-0.334	<.001	<.001	3	5
LUNG_SCLC	ECSIT →	-0.628	-0.239	.008	<.001	3	5
PANCREAS	CLUH →	-0.925	-0.270	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002028 vs PHB — LIVER

Explore this scatter interactively →