Regulation of the force of heart contraction

Across TCGA patient cohorts, RNA activity of the Regulation of the force of heart contraction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH6, KPNB1, and UTP18, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of the force of heart contraction activity versus MSH6 in LSCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSH6 →	-0.541	-0.157	.001	<.001	3	6
LSCC	KPNB1 →	-0.435	-0.160	<.001	<.001	3	5
UCEC	UTP18 →	-0.523	-0.180	<.001	<.001	3	5
UCEC	DDX46 →	-0.344	-0.185	<.001	<.001	3	5
UCEC	SRSF2 →	-0.428	-0.162	<.001	<.001	3	5
UCEC	RFC4 →	-0.760	-0.198	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002026 vs MSH6 — LSCC

Explore this scatter interactively →