Diet induced thermogenesis

Across TCGA patient cohorts, RNA activity of the Diet induced thermogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKA1, SRPK1, and TCOF1_S1378, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diet induced thermogenesis activity versus SKA1 in LUAD (Pearson r = -0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SKA1 →	-0.850	-0.071	.002	.009	3	5
GBM	SRPK1 →	-0.294	-0.060	.001	<.001	3	5
UCEC	TCOF1_S1378 →	-0.414	-0.054	.005	<.001	2	6
GBM	CRK_S125 →	+0.380	+0.053	.007	.001	3	5
GBM	GPATCH4 →	-0.381	-0.047	.002	.001	3	5
LSCC	WDR91 →	+0.226	+0.053	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002024 vs SKA1 — LUAD

Explore this scatter interactively →