Diet induced thermogenesis

Across TCGA patient cohorts, RNA activity of the Diet induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPF1, LINC02688, and MTFR2P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diet induced thermogenesis activity versus DPF1 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DPF1 →	-0.467	-0.850	<.001	<.001	3	4
LSCC	LINC02688 →	+0.122	+0.404	.006	.008	3	4
PDAC	MTFR2P2 →	-0.169	-0.624	.009	.002	3	3
COAD	CENPO →	-0.414	-0.120	.004	.003	2	4
COAD	TMSB15B →	-0.108	-0.118	.001	.002	3	3
LUAD	PRKAB1 →	+0.358	+0.504	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002024 vs DPF1 — LSCC

Explore this scatter interactively →