Diet induced thermogenesis

Across TCGA cell cohorts, RNA activity of the Diet induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OMA1, SORL1, and BMP8A, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diet induced thermogenesis activity versus OMA1 in URINARY_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OMA1 →	+1.196	+0.219	<.001	.001	3	11
PANCREAS	SORL1 →	+2.554	+0.531	<.001	.006	3	10
CNS	BMP8A →	-0.154	-0.105	.003	.003	3	8
CNS	SCARF2 →	-1.192	-0.158	.002	.001	3	8
LARGE_INTESTINE	DBN1 →	-2.202	-0.201	<.001	<.001	3	7
STOMACH	OBSL1 →	-2.417	-0.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002024 vs OMA1 — URINARY_TRACT

Explore this scatter interactively →