Regulation of blood volume by renin-angiotensin

Across TCGA patient cohorts, RNA activity of the Regulation of blood volume by renin-angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPE1P10, GPIHBP1, and DGCR8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood volume by renin-angiotensin activity versus HSPE1P10 in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPE1P10 →	+0.246	+0.606	.002	.001	3	3
GBM	GPIHBP1 →	+0.837	+0.362	<.001	.004	2	4
GBM	DGCR8 →	-0.316	-0.398	.002	<.001	3	3
GBM	TNFSF13 →	+0.432	+0.318	.006	.001	3	3
GBM	RBM47 →	+0.571	+0.297	.007	.001	3	3
BRCA	MAP1A →	+0.601	+0.579	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002016 vs HSPE1P10 — UCEC

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