Morphogenesis of an epithelial sheet

Across TCGA patient cohorts, RNA activity of the Morphogenesis of an epithelial sheet pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, TIMP2, and RAI14, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an epithelial sheet activity versus NID2 in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NID2 →	+0.622	+0.059	<.001	<.001	3	9
BRCA	TIMP2 →	+0.551	+0.033	<.001	<.001	3	9
BRCA	RAI14 →	+0.375	+0.049	<.001	<.001	3	9
OV	CLEC3B →	+0.656	+0.049	<.001	.002	3	9
OV	SERPINA4 →	+0.608	+0.064	<.001	<.001	3	8
BRCA	SERPINF1 →	+0.699	+0.036	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002011 vs NID2 — GBM

Explore this scatter interactively →