Regulation of angiotensin levels in blood

Across TCGA patient cohorts, RNA activity of the Regulation of angiotensin levels in blood pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRPK1, PIP4K2A, and PPP1R12C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of angiotensin levels in blood activity versus SRPK1 in GBM (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRPK1 →	-0.305	-0.094	<.001	<.001	3	6
GBM	PIP4K2A →	+0.610	+0.091	<.001	<.001	3	6
LSCC	PPP1R12C →	+0.304	+0.104	<.001	<.001	3	6
LSCC	SMARCA4 →	-0.392	-0.075	.002	.002	3	5
LSCC	SSRP1 →	-0.526	-0.120	<.001	<.001	3	5
GBM	SUPT16H →	-0.424	-0.079	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002002 vs SRPK1 — GBM

Explore this scatter interactively →