Regulation of angiotensin levels in blood

Across TCGA cell cohorts, RNA activity of the Regulation of angiotensin levels in blood pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIMS3, BRD1, and KRBA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of angiotensin levels in blood activity versus RIMS3 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIMS3 →	-2.082	-0.558	<.001	.005	3	3
LARGE_INTESTINE	BRD1 →	-0.619	-0.814	.001	.009	2	4
URINARY_TRACT	KRBA1 →	-0.622	-0.251	.009	.006	3	3
URINARY_TRACT	MPHOSPH6 →	-0.714	-0.271	.008	.009	3	3
BLOOD_Leukemia	CASK →	-1.461	-0.641	.002	.009	3	3
URINARY_TRACT	CACNB3 →	-1.017	-0.190	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002002 vs RIMS3 — BLOOD_Leukemia

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