Regulation of systemic arterial blood pressure by vasopressin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by vasopressin pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAT8L, HPCAL4, and PNLIPRP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAT8L grouped by Regulation of systemic arterial blood pressure by vasopressin-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NAT8L →	+0.161	+0.219	.009	.001	3	4
SOFT_TISSUE	HPCAL4 →	-0.188	-1.463	.002	.009	3	3
BLOOD_Myeloma	PNLIPRP2 →	-0.368	-0.076	.006	.008	3	3
LUNG_SCLC	CARD8 →	+0.277	+0.189	.002	<.001	3	3
LARGE_INTESTINE	KL →	+0.180	+0.114	<.001	.002	3	3
LARGE_INTESTINE	ARHGEF11 →	+0.125	+0.120	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAT8L by Regulation of systemic arterial blood pressure by vasopressin activity — BONE

Explore this box plot interactively →