Nervous system process involved in regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Nervous system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAV2, NAV2-AS2, and CENPN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nervous system process involved in regulation of systemic arterial blood pressure activity versus NAV2 in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NAV2 →	+0.895	+0.422	<.001	<.001	3	4
LUAD	NAV2-AS2 →	+0.290	+0.239	.006	.007	3	4
GBM	CENPN →	-0.409	-0.299	.002	.002	3	4
LSCC	CDKL2 →	+0.681	+0.359	.004	.003	3	3
LUAD	KISS1R →	+0.632	+0.269	<.001	.002	3	3
LUAD	POLE3 →	-0.268	-0.389	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001976 vs NAV2 — LSCC

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